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In vivo anticancer activity of a rhodium metalloinsertor in the HCT116 xenograft tumor model
Mismatch repair (MMR) deficiencies are a hallmark of various cancers causing accumulation of DNA mutations and mismatches, which often results in chemotherapy resistance. Metalloinsertor complexes, including [Rh(chrysi)(phen)(PPO)]Cl(2) (Rh-PPO), specifically target DNA mismatches and selectively in...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395490/ https://www.ncbi.nlm.nih.gov/pubmed/32661159 http://dx.doi.org/10.1073/pnas.2006569117 |