Type I IFN is siloed in endosomes

Type I IFN (IFN-I) is thought to be rapidly internalized and degraded following binding to its receptor and initiation of signaling. However, many studies report the persistent effects mediated by IFN-I for days or even weeks, both ex vivo and in vivo. These long-lasting effects are attributed to do...

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Detalles Bibliográficos
Autores principales: Altman, Jennie B., Taft, Justin, Wedeking, Tim, Gruber, Conor N., Holtmannspötter, Michael, Piehler, Jacob, Bogunovic, Dusan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395562/
https://www.ncbi.nlm.nih.gov/pubmed/32665439
http://dx.doi.org/10.1073/pnas.1921324117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395562/
https://www.ncbi.nlm.nih.gov/pubmed/32665439
http://dx.doi.org/10.1073/pnas.1921324117

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