Mutation accumulation and developmental lineages in normal and Down syndrome human fetal haematopoiesis

Children show a higher incidence of leukemia compared to young adolescents, yet their cells have less age-related (oncogenic) somatic mutations. Newborns with Down syndrome have an even higher risk of developing leukemia, which is thought to be driven by mutations that accumulate during fetal develo...

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Detalles Bibliográficos
Autores principales: Hasaart, Karlijn A. L., Manders, Freek, van der Hoorn, Marie-Louise, Verheul, Mark, Poplonski, Tomasz, Kuijk, Ewart, de Sousa Lopes, Susana M. Chuva, van Boxtel, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395765/
https://www.ncbi.nlm.nih.gov/pubmed/32737409
http://dx.doi.org/10.1038/s41598-020-69822-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395765/
https://www.ncbi.nlm.nih.gov/pubmed/32737409
http://dx.doi.org/10.1038/s41598-020-69822-1

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