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Mutation accumulation and developmental lineages in normal and Down syndrome human fetal haematopoiesis
Children show a higher incidence of leukemia compared to young adolescents, yet their cells have less age-related (oncogenic) somatic mutations. Newborns with Down syndrome have an even higher risk of developing leukemia, which is thought to be driven by mutations that accumulate during fetal develo...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395765/ https://www.ncbi.nlm.nih.gov/pubmed/32737409 http://dx.doi.org/10.1038/s41598-020-69822-1 |