Testing and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies

Integrating results from genome-wide association studies (GWASs) and gene expression studies through transcriptome-wide association study (TWAS) has the potential to shed light on the causal molecular mechanisms underlying disease etiology. Here, we present a probabilistic Mendelian randomization (M...

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Detalles Bibliográficos
Autores principales: Yuan, Zhongshang, Zhu, Huanhuan, Zeng, Ping, Yang, Sheng, Sun, Shiquan, Yang, Can, Liu, Jin, Zhou, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395774/
https://www.ncbi.nlm.nih.gov/pubmed/32737316
http://dx.doi.org/10.1038/s41467-020-17668-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395774/
https://www.ncbi.nlm.nih.gov/pubmed/32737316
http://dx.doi.org/10.1038/s41467-020-17668-6

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