Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

Polygenic scores (PGS) have been widely used to predict disease risk using variants identified from genome-wide association studies (GWAS). To date, most GWAS have been conducted in populations of European ancestry, which limits the use of GWAS-derived PGS in non-European ancestry populations. Here,...

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Detalles Bibliográficos
Autores principales: Wang, Ying, Guo, Jing, Ni, Guiyan, Yang, Jian, Visscher, Peter M., Yengo, Loic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395791/
https://www.ncbi.nlm.nih.gov/pubmed/32737319
http://dx.doi.org/10.1038/s41467-020-17719-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395791/
https://www.ncbi.nlm.nih.gov/pubmed/32737319
http://dx.doi.org/10.1038/s41467-020-17719-y

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