Pyroptotic cell death in the R6/2 mouse model of Huntington’s disease: new insight on the inflammasome

Mechanisms of tissue damage in Huntington’s disease involve excitotoxicity, mitochondrial damage, and neuroinflammation, including microglia activation. In the present study, we investigate the role of pyroptosis process in the striatal neurons of the R6/2 mouse model of Huntington’s disease. Transg...

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Detalles Bibliográficos
Autores principales: Paldino, Emanuela, D’Angelo, Vincenza, Sancesario, Giuseppe, Fusco, Francesca R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395807/
https://www.ncbi.nlm.nih.gov/pubmed/32821438
http://dx.doi.org/10.1038/s41420-020-00293-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395807/
https://www.ncbi.nlm.nih.gov/pubmed/32821438
http://dx.doi.org/10.1038/s41420-020-00293-z

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