3,6-Disubstituted 1,2,4-Triazolo[3,4-b]Thiadiazoles with Anticancer Activity Targeting Topoisomerase II Alpha

BACKGROUND: Topoisomerase IIα (topIIα) maintains the topology of DNA in order to ensure the proper functioning of numerous DNA processes. Inhibition of topIIα leads to the killing of cancer cells thus constituting such inhibitors as useful tools in cancer therapeutics. Triazolo[3,4-b]thiadiazole der...

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Detalles Bibliográficos
Autores principales: Sagredou, Sofia, Dalezis, Panagiotis, Nikoleousakos, Nikolaos, Nikolaou, Michail, Voura, Maria, Almpanakis, Konstantinos, Panayiotidis, Mihalis I, Sarli, Vasiliki, Trafalis, Dimitrios T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395825/
https://www.ncbi.nlm.nih.gov/pubmed/32801761
http://dx.doi.org/10.2147/OTT.S254856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395825/
https://www.ncbi.nlm.nih.gov/pubmed/32801761
http://dx.doi.org/10.2147/OTT.S254856

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