Nonclinical Pharmacokinetic and Pharmacodynamic Assessment of Bimatoprost Following a Single Intracameral Injection of Sustained-Release Implants

PURPOSE: To assess the pharmacokinetic (PK)/pharmacodynamic (PD) relationship following intracameral Bimatoprost sustained-release (SR) implants (8, 15, 30, and 60 µg) in dogs to determine the optimal investigative dose in humans. METHODS: Forty-four male normotensive beagle dogs were assigned to 1...

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Detalles Bibliográficos
Autores principales: Shen, Jie, Robinson, Michael R., Struble, Craig, Attar, Mayssa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396179/
https://www.ncbi.nlm.nih.gov/pubmed/32818107
http://dx.doi.org/10.1167/tvst.9.4.20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396179/
https://www.ncbi.nlm.nih.gov/pubmed/32818107
http://dx.doi.org/10.1167/tvst.9.4.20

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