Cargando…

Nonclinical Pharmacokinetic and Pharmacodynamic Assessment of Bimatoprost Following a Single Intracameral Injection of Sustained-Release Implants

PURPOSE: To assess the pharmacokinetic (PK)/pharmacodynamic (PD) relationship following intracameral Bimatoprost sustained-release (SR) implants (8, 15, 30, and 60 µg) in dogs to determine the optimal investigative dose in humans. METHODS: Forty-four male normotensive beagle dogs were assigned to 1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shen, Jie, Robinson, Michael R., Struble, Craig, Attar, Mayssa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396179/ https://www.ncbi.nlm.nih.gov/pubmed/32818107 http://dx.doi.org/10.1167/tvst.9.4.20

Ejemplares similares

Intracameral Sustained-Release Bimatoprost Implant Delivers Bimatoprost to Target Tissues with Reduced Drug Exposure to Off-Target Tissues
por: Seal, Jennifer R., et al.
Publicado: (2019)

Dose–Response of Intracameral Bimatoprost Sustained-Release Implant and Topical Bimatoprost in Lowering Intraocular Pressure
por: Lee, Susan S., et al.
Publicado: (2019)

Ocular pharmacokinetics and tolerability of bimatoprost ophthalmic solutions administered once or twice daily in rabbits, and clinical dosing implications
por: Shen, Jie, et al.
Publicado: (2017)

24-Month Phase I/II Clinical Trial of Bimatoprost Sustained-Release Implant (Bimatoprost SR) in Glaucoma Patients
por: Craven, E. Randy, et al.
Publicado: (2019)

The biodisposition and hypertrichotic effects of bimatoprost in mouse skin
por: Woodward, David F, et al.
Publicado: (2013)

Distribution of (14)C-Latanoprost Following a Single Intracameral Administration Versus Repeated Topical Administration
por: Shen, Jie, et al.
Publicado: (2020)

Single Administration of Intracameral Bimatoprost Implant 10 µg in Patients with Open-Angle Glaucoma or Ocular Hypertension
por: Medeiros, Felipe A., et al.
Publicado: (2022)

Intraocular Pressure Effects and Mechanism of Action of Topical Versus Sustained-Release Bimatoprost
por: Lee, Susan S., et al.
Publicado: (2019)

Nonclinical analysis of the safety, pharmacodynamics, and pharmacokinetics of plasma‐derived human FXIII concentrate in animals
por: Beyerle, Andrea, et al.
Publicado: (2016)

Intraocular Pressure-Lowering Efficacy of a Sustained-Release Bimatoprost Implant in Dog Eyes Pretreated with Selective Laser Trabeculoplasty
por: Ghosn, Corine, et al.
Publicado: (2022)

Biocompatibility and Pharmacokinetic Analysis of an Intracameral Polycaprolactone Drug Delivery Implant for Glaucoma
por: Kim, Jean, et al.
Publicado: (2016)

Phase 3, Randomized Study Comparing Intracameral Bimatoprost Implant 15 µg and Selective Laser Trabeculectomy in Patients with Open-Angle Glaucoma or Ocular Hypertension
por: Christie, William C, et al.
Publicado: (2023)

Bimatoprost Implant: First Approval
por: Shirley, Matt
Publicado: (2020)

Pharmacokinetic-Pharmacodynamic Model of Newly Developed Dexibuprofen Sustained Release Formulations
por: Muralidharan, Selvadurai
Publicado: (2012)

Comparison of intracameral dexamethasone and intracameral triamcinolone acetonide injection at the end of phacoemulsification surgery
por: Güngör, Sirel Gür, et al.
Publicado: (2014)

Comparison of intracameral dexamethasone and intracameral triamcinolone acetonide injection at the end of phacoemulsification surgery
por: Ozge, Gokhan, et al.
Publicado: (2015)

Correction to: Bimatoprost Implant: First Approval
por: Shirley, Matt
Publicado: (2020)

Intracameral migration of collagen matrix implant
por: Phogat, Jitender, et al.
Publicado: (2019)

Ocular pharmacokinetics of bimatoprost formulated in DuraSite compared to bimatoprost 0.03% ophthalmic solution in pigmented rabbit eyes
por: Shafiee, Afshin, et al.
Publicado: (2013)

Intracameral Injection of Methotrexate for Treatment of Epithelial Ingrowth
por: Salari, Farhad, et al.
Publicado: (2022)

Ophthalmic Bimatoprost-Loaded Niosomal In Situ Gel: Preparation, Optimization, and In Vivo Pharmacodynamics Study
por: Aldawsari, Mohammed F., et al.
Publicado: (2023)

Review article: nonclinical and clinical pharmacology, pharmacokinetics and pharmacodynamics of etrolizumab, an anti‐β7 integrin therapy for inflammatory bowel disease
por: Tang, M. T., et al.
Publicado: (2018)

Proposed Mechanism of Long-Term Intraocular Pressure Lowering With the Bimatoprost Implant
por: Stamer, W. Daniel, et al.
Publicado: (2023)

Bimatoprost in Dermatology
por: Jha, Abhijeet K., et al.
Publicado: (2018)

Descemet's membrane detachment following an intracameral injection of viscoelastic
por: Bowden, Eileen Choudhury, et al.
Publicado: (2019)

Management of acute corneal hydrops with intracameral gas injection
por: Sayadi, Jamasb J., et al.
Publicado: (2020)

Bimatoprost Implant Biodegradation in the Phase 3, Randomized, 20-Month ARTEMIS Studies
por: Weinreb, Robert N., et al.
Publicado: (2023)

Bimatoprost-Loaded Ocular Inserts as Sustained Release Drug Delivery Systems for Glaucoma Treatment: In Vitro and In Vivo Evaluation
por: Franca, Juçara Ribeiro, et al.
Publicado: (2014)

OTO-201: Nonclinical Assessment of a Sustained-Release Ciprofloxacin Hydrogel for the Treatment of Otitis Media
por: Wang, Xiaobo, et al.
Publicado: (2014)

Nonclinical safety, tolerance and pharmacodynamics evaluation for meplazumab treating chloroquine-resistant Plasmodium falciparum
por: Zhang, Kun, et al.
Publicado: (2020)

Toxic anterior segment syndrome and intracameral injection of cefuroxime axetil
por: Gardner, Susanne, et al.
Publicado: (2015)

Pharmacodynamics and pharmacokinetics of ciprofloxacin during sustained low-efficiency dialysis
por: Olsen, K, et al.
Publicado: (2014)

Ocular pharmacokinetics of 0.45% ketorolac tromethamine
por: Attar, Mayssa, et al.
Publicado: (2010)

Pharmacokinetic and Pharmacodynamic Variability of Insulin When Administered by Jet Injection
por: Engwerda, Elsemiek E. C., et al.
Publicado: (2017)

Effect of intracameral injection of fibrin tissue sealant on the rabbit anterior segment
por: Chew, Annabel C.Y., et al.
Publicado: (2010)

Impact of topical bimatoprost 0.01% and bimatoprost 0.03% on conjunctival irritation in rabbits
por: Ogundele, Abayomi B, et al.
Publicado: (2010)

Aqueous humor penetration of topical bimatoprost 0.01% and bimatoprost 0.03% in rabbits
por: Ogundele, Abayomi B, et al.
Publicado: (2010)

Prediction of Human Pharmacokinetics of Antibody–Drug Conjugates From Nonclinical Data
por: Li, Chunze, et al.
Publicado: (2019)

OSWG Recommended Approaches to the Nonclinical Pharmacokinetic (ADME) Characterization of Therapeutic Oligonucleotides
por: Berman, Cindy L., et al.
Publicado: (2023)

Single ocular injection of a sustained-release anti-VEGF delivers 6 months pharmacokinetics and efficacy in a primate laser CNV model
por: Adamson, Peter, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_43bajhfpkmlm6m0i0gcfat4nf8