Cargando…

High‐resolution crystal structures of the botulinum neurotoxin binding domains from subtypes A5 and A6

Clostridium botulinum neurotoxins (BoNTs) cause flaccid paralysis through inhibition of acetylcholine release from motor neurons; however, at tiny doses, this property is exploited for use as a therapeutic. Each member of the BoNT family of proteins consists of three distinct domains: a binding doma...

Descripción completa

Detalles Bibliográficos
Autores principales: Davies, Jonathan R., Britton, Amy, Liu, Sai Man, Acharya, K. Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396429/
https://www.ncbi.nlm.nih.gov/pubmed/32654405
http://dx.doi.org/10.1002/2211-5463.12931