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High‐resolution crystal structures of the botulinum neurotoxin binding domains from subtypes A5 and A6
Clostridium botulinum neurotoxins (BoNTs) cause flaccid paralysis through inhibition of acetylcholine release from motor neurons; however, at tiny doses, this property is exploited for use as a therapeutic. Each member of the BoNT family of proteins consists of three distinct domains: a binding doma...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396429/ https://www.ncbi.nlm.nih.gov/pubmed/32654405 http://dx.doi.org/10.1002/2211-5463.12931 |