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Mutations in the TolC Periplasmic Domain Affect Substrate Specificity of the AcrAB-TolC Pump
TolC and the other members of the outer membrane factor (OMF) family are outer membrane proteins forming trimeric channels that serve as a conduit for most actively effluxed substrates in Gram-negative bacteria by providing a key component in a multitude of tripartite efflux-pumps. Current models of...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396618/ https://www.ncbi.nlm.nih.gov/pubmed/32850959 http://dx.doi.org/10.3389/fmolb.2020.00166 |