Cargando…

Stabilization of HIF-1α in Human Retinal Endothelial Cells Modulates Expression of miRNAs and Proangiogenic Growth Factors

Retinal hypoxia is one of the causative factors of diabetic retinopathy and is also one of the triggers of VEGF release. We hypothesized that specific dysregulated miRNAs in diabetic retinopathy could be linked to hypoxia-induced damage in human retinal endothelial cells (HRECs). We investigated in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lazzara, Francesca, Trotta, Maria Consiglia, Platania, Chiara Bianca Maria, D’Amico, Michele, Petrillo, Francesco, Galdiero, Marilena, Gesualdo, Carlo, Rossi, Settimio, Drago, Filippo, Bucolo, Claudio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396674/ https://www.ncbi.nlm.nih.gov/pubmed/32848728 http://dx.doi.org/10.3389/fphar.2020.01063

Ejemplares similares

Resolvin D1 Modulates the Intracellular VEGF-Related miRNAs of Retinal Photoreceptors Challenged With High Glucose
por: Maisto, Rosa, et al.
Publicado: (2020)

Corrigendum: Resolvin D1 Modulates the Intracellular VEGF-Related miRNAs of Retinal Photoreceptors Challenged With High Glucose
por: Maisto, Rosa, et al.
Publicado: (2020)

Editorial: Chronic Inflammation and Neurodegeneration in Retinal Disease
por: Petrillo, Francesco, et al.
Publicado: (2021)

Vitamin D(3) preserves blood retinal barrier integrity in an in vitro model of diabetic retinopathy
por: Lazzara, Francesca, et al.
Publicado: (2022)

Changes in Retinal Structure and Ultrastructure in the Aged Mice Correlate With Differences in the Expression of Selected Retinal miRNAs
por: Hermenean, Anca, et al.
Publicado: (2021)

Corrigendum: Changes in Retinal Structure and Ultrastructure in the Aged Mice Correlate with Differences in the Expression of Selected Retinal miRNAs
por: Hermenean, Anca, et al.
Publicado: (2021)

Serum Iba-1, GLUT5, and TSPO in Patients With Diabetic Retinopathy: New Biomarkers for Early Retinal Neurovascular Alterations? A Pilot Study
por: Trotta, Maria Consiglia, et al.
Publicado: (2022)

Caffeine Protects Against Retinal Inflammation
por: Conti, Federica, et al.
Publicado: (2022)

Resolution of Inflammation in Retinal Disorders: Briefly the State
por: Trotta, Maria Consiglia, et al.
Publicado: (2022)

Effects of Vitamin D(3) and Meso-Zeaxanthin on Human Retinal Pigmented Epithelial Cells in Three Integrated in vitro Paradigms of Age-Related Macular Degeneration
por: Lazzara, Francesca, et al.
Publicado: (2021)

Fingolimod and Diabetic Retinopathy: A Drug Repurposing Study
por: Gesualdo, Carlo, et al.
Publicado: (2021)

Melanocortin receptor agonists MCR (1‐5) protect photoreceptors from high‐glucose damage and restore antioxidant enzymes in primary retinal cell culture
por: Maisto, Rosa, et al.
Publicado: (2016)

Sex and Age-Related Differences in Neuroinflammation and Apoptosis in Balb/c Mice Retina Involve Resolvin D1
por: Trotta, Maria Consiglia, et al.
Publicado: (2021)

Effects of the Calix[4]arene Derivative Compound OTX008 on High Glucose-Stimulated ARPE-19 Cells: Focus on Galectin-1/TGF-β/EMT Pathway
por: Trotta, Maria Consiglia, et al.
Publicado: (2022)

Effects of Novel Nitric Oxide-Releasing Molecules against Oxidative Stress on Retinal Pigmented Epithelial Cells
por: Pittalà, Valeria, et al.
Publicado: (2017)

Resolvin D1 attenuates the inflammatory process in mouse model of LPS‐induced keratitis
por: Petrillo, Francesco, et al.
Publicado: (2020)

1α,25-dihydroxyvitamin D(3) protects retinal ganglion cells in glaucomatous mice
por: Lazzara, Francesca, et al.
Publicado: (2021)

Novel ophthalmic formulation of myriocin: implications in retinitis pigmentosa
por: Platania, Chiara Bianca Maria, et al.
Publicado: (2019)

The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome
por: Trotta, Maria Consiglia, et al.
Publicado: (2019)

High Levels of Serum Ubiquitin and Proteasome in a Case of HLA-B27 Uveitis
por: Rossi, Settimio, et al.
Publicado: (2017)

Autophagy: A Novel Pharmacological Target in Diabetic Retinopathy
por: Adornetto, Annagrazia, et al.
Publicado: (2021)

Retinal Protection and Distribution of Curcumin in Vitro and in Vivo
por: Platania, Chiara B. M., et al.
Publicado: (2018)

Oral Administration of Vitamin D3 Prevents Corneal Damage in a Knock-Out Mouse Model of Sjögren’s Syndrome
por: Trotta, Maria Consiglia, et al.
Publicado: (2023)

Inhibition of Galectins and the P2X7 Purinergic Receptor as a Therapeutic Approach in the Neurovascular Inflammation of Diabetic Retinopathy
por: Lepre, Caterina Claudia, et al.
Publicado: (2023)

Dihydrotanshinone, a Natural Diterpenoid, Preserves Blood-Retinal Barrier Integrity via P2X7 Receptor
por: Fresta, Claudia Giuseppina, et al.
Publicado: (2020)

Safety Profile of Lutein- Versus Triamcinolone Acetonide–Based Vitreous Staining
por: Lazzara, Francesca, et al.
Publicado: (2023)

New Brilliant Blue G Derivative as Pharmacological Tool in Retinal Surgery
por: Spadaro, Angelo, et al.
Publicado: (2020)

Topical Ocular Delivery of TGF-β1 to the Back of the Eye: Implications in Age-Related Neurodegenerative Diseases
por: Platania, Chiara Bianca Maria, et al.
Publicado: (2017)

Editorial: Chronic Inflammation and Neurodegeneration in Retinal Disease, Volume II
por: Bucolo, Claudio, et al.
Publicado: (2022)

Homology Modeling of Dopamine D(2) and D(3) Receptors: Molecular Dynamics Refinement and Docking Evaluation
por: Platania, Chiara Bianca Maria, et al.
Publicado: (2012)

Correction: Homology Modeling of Dopamine D(2) and D(3) Receptors: Molecular Dynamics Refinement and Docking Evaluation
por: Platania, Chiara Bianca Maria, et al.
Publicado: (2013)

Circulating MiRNA-195-5p and -451a in Diabetic Patients with Transient and Acute Ischemic Stroke in the Emergency Department
por: Giordano, Mauro, et al.
Publicado: (2020)

Retinal and Circulating miRNAs in Age-Related Macular Degeneration: An In vivo Animal and Human Study
por: Romano, Giovanni L., et al.
Publicado: (2017)

Systemic Beta-Hydroxybutyrate Affects BDNF and Autophagy into the Retina of Diabetic Mice
por: Trotta, Maria Consiglia, et al.
Publicado: (2022)

Fortified Extract of Red Berry, Ginkgo biloba, and White Willow Bark in Experimental Early Diabetic Retinopathy
por: Bucolo, Claudio, et al.
Publicado: (2013)

Novel Therapeutics in Glaucoma Management
por: Bucolo, Claudio, et al.
Publicado: (2018)

Carnosine Counteracts the Molecular Alterations Aβ Oligomers-Induced in Human Retinal Pigment Epithelial Cells
por: Caruso, Giuseppe, et al.
Publicado: (2023)

Ocular Pharmacological Profile of Hydrocortisone in Dry Eye Disease
por: Bucolo, Claudio, et al.
Publicado: (2019)

Molecular features of interaction between VEGFA and anti-angiogenic drugs used in retinal diseases: a computational approach
por: Platania, Chiara B. M., et al.
Publicado: (2015)

TGF-β Serum Levels in Diabetic Retinopathy Patients and the Role of Anti-VEGF Therapy
por: Bonfiglio, Vincenza, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_5ajt39na50476v6mf1r83bh35a