Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System

The classical pathway of complement is important for protection against pathogens and in maintaining tissue homeostasis, but excessive or aberrant activation is directly linked to numerous pathologies. We describe the development and in vitro characterization of C1qNb75, a single domain antibody (na...

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Detalles Bibliográficos
Autores principales: Laursen, Nick S., Pedersen, Dennis V., Gytz, Heidi, Zarantonello, Alessandra, Bernth Jensen, Jens Magnus, Hansen, Annette G., Thiel, Steffen, Andersen, Gregers R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396675/
https://www.ncbi.nlm.nih.gov/pubmed/32849513
http://dx.doi.org/10.3389/fimmu.2020.01504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396675/
https://www.ncbi.nlm.nih.gov/pubmed/32849513
http://dx.doi.org/10.3389/fimmu.2020.01504

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