The Grapefruit Effect: Interaction between Cytochrome P450 and Coumarin Food Components, Bergamottin, Fraxidin and Osthole. X-ray Crystal Structure and DFT Studies

Coumarins are plant-derived secondary metabolites. The crystal structure of three coumarins—bergamottin, osthole and fraxidin—are described and we analyze intermolecular interactions and their role in crystal formation. Bergamottin is a furanocoumarin found in citrus plants, which is a strong inhibi...

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Detalles Bibliográficos
Autores principales: Rossi, Miriam, Aktar, Sandjida, Davis, Marissa, Hefter Feuss, Emily, Roman-Holba, Samara, Wen, Kelly, Gahn, Christopher, Caruso, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397038/
https://www.ncbi.nlm.nih.gov/pubmed/32664320
http://dx.doi.org/10.3390/molecules25143158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397038/
https://www.ncbi.nlm.nih.gov/pubmed/32664320
http://dx.doi.org/10.3390/molecules25143158

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