Two clusters of surface-exposed amino acid residues enable high-affinity binding of retinal degeneration-3 (RD3) protein to retinal guanylyl cyclase

Retinal degeneration-3 (RD3) protein protects photoreceptors from degeneration by preventing retinal guanylyl cyclase (RetGC) activation via calcium-sensing guanylyl cyclase–activating proteins (GCAP), and RD3 truncation causes severe congenital blindness in humans and other animals. The three-dimen...

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Detalles Bibliográficos
Autores principales: Peshenko, Igor V., Dizhoor, Alexander M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397094/
https://www.ncbi.nlm.nih.gov/pubmed/32493772
http://dx.doi.org/10.1074/jbc.RA120.013789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397094/
https://www.ncbi.nlm.nih.gov/pubmed/32493772
http://dx.doi.org/10.1074/jbc.RA120.013789

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