The Parkinson's disease–associated kinase LRRK2 regulates genes required for cell adhesion, polarization, and chemotaxis in activated murine macrophages

Leucine-rich repeat kinase 2 (LRRK2) encodes a complex protein that includes kinase and GTPase domains. Genome-wide association studies have identified dominant LRRK2 alleles that predispose their carriers to late-onset idiotypic Parkinson's disease (PD) and also to autoimmune disorders such as...

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Detalles Bibliográficos
Autores principales: Levy, Daniel R., Udgata, Atul, Tourlomousis, Panagiotis, Symmons, Martyn F., Hopkins, Lee J., Bryant, Clare E., Gay, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Gene Regulation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397110/
https://www.ncbi.nlm.nih.gov/pubmed/32111741
http://dx.doi.org/10.1074/jbc.RA119.011842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397110/
https://www.ncbi.nlm.nih.gov/pubmed/32111741
http://dx.doi.org/10.1074/jbc.RA119.011842

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