Second-Generation Pharmacological Chaperones: Beyond Inhibitors

Protein misfolding induced by missense mutations is the source of hundreds of conformational diseases. The cell quality control may eliminate nascent misfolded proteins, such as enzymes, and a pathological loss-of-function may result from their early degradation. Since the proof of concept in the 20...

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Detalles Bibliográficos
Autores principales: Tran, My Lan, Génisson, Yves, Ballereau, Stéphanie, Dehoux, Cécile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397201/
https://www.ncbi.nlm.nih.gov/pubmed/32660097
http://dx.doi.org/10.3390/molecules25143145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397201/
https://www.ncbi.nlm.nih.gov/pubmed/32660097
http://dx.doi.org/10.3390/molecules25143145

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