Properly Substituted Cyclic Bis-(2-bromobenzylidene) Compounds Behaved as Dual p300/CARM1 Inhibitors and Induced Apoptosis in Cancer Cells

Bis-(3-bromo-4-hydroxy)benzylidene cyclic compounds have been reported by us as epigenetic multiple ligands, but different substitutions at the two wings provided analogues with selective inhibition. Since the 1-benzyl-3,5-bis((E)-3-bromobenzylidene)piperidin-4-one 3 displayed dual p300/EZH2 inhibit...

Descripción completa

Detalles Bibliográficos
Autores principales: Fioravanti, Rossella, Tomassi, Stefano, Di Bello, Elisabetta, Romanelli, Annalisa, Plateroti, Andrea Maria, Benedetti, Rosaria, Conte, Mariarosaria, Novellino, Ettore, Altucci, Lucia, Valente, Sergio, Mai, Antonello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397249/
https://www.ncbi.nlm.nih.gov/pubmed/32650558
http://dx.doi.org/10.3390/molecules25143122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397249/
https://www.ncbi.nlm.nih.gov/pubmed/32650558
http://dx.doi.org/10.3390/molecules25143122

Ejemplares similares