Synthesis of Triazole-Linked SAM-Adenosine Conjugates: Functionalization of Adenosine at N-1 or N-6 Position without Protecting Groups

More than 150 RNA chemical modifications have been identified to date. Among them, methylation of adenosine at the N-6 position (m(6)A) is crucial for RNA metabolism, stability and other important biological events. In particular, this is the most abundant mark found in mRNA in mammalian cells. The...

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Detalles Bibliográficos
Autores principales: Atdjian, Colette, Coelho, Dylan, Iannazzo, Laura, Ethève-Quelquejeu, Mélanie, Braud, Emmanuelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397255/
https://www.ncbi.nlm.nih.gov/pubmed/32708658
http://dx.doi.org/10.3390/molecules25143241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397255/
https://www.ncbi.nlm.nih.gov/pubmed/32708658
http://dx.doi.org/10.3390/molecules25143241

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