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Synthesis of Triazole-Linked SAM-Adenosine Conjugates: Functionalization of Adenosine at N-1 or N-6 Position without Protecting Groups
More than 150 RNA chemical modifications have been identified to date. Among them, methylation of adenosine at the N-6 position (m(6)A) is crucial for RNA metabolism, stability and other important biological events. In particular, this is the most abundant mark found in mRNA in mammalian cells. The...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397255/ https://www.ncbi.nlm.nih.gov/pubmed/32708658 http://dx.doi.org/10.3390/molecules25143241 |