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Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer’s Disease

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder that involves different pathogenic mechanisms. In this regard, the goal of this study was the design and synthesis of new compounds with multifunctional pharmacological activity by molecular hybridization of structural fragments...

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Detalles Bibliográficos
Autores principales: de Freitas Silva, Matheus, Tardelli Lima, Ellen, Pruccoli, Letizia, Castro, Newton G., Guimarães, Marcos Jorge R., da Silva, Fernanda M. R., Fonseca Nadur, Nathalia, de Azevedo, Luciana Luiz, Kümmerle, Arthur Eugen, Guedes, Isabella Alvim, Dardenne, Laurent Emmanuel, Gontijo, Vanessa Silva, Tarozzi, Andrea, Viegas, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397262/
https://www.ncbi.nlm.nih.gov/pubmed/32664425
http://dx.doi.org/10.3390/molecules25143165