Limitations and challenges in protein stability prediction upon genome variations: towards future applications in precision medicine

Protein stability predictions are becoming essential in medicine to develop novel immunotherapeutic agents and for drug discovery. Despite the large number of computational approaches for predicting the protein stability upon mutation, there are still critical unsolved problems: 1) the limited numbe...

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Detalles Bibliográficos
Autores principales: Sanavia, Tiziana, Birolo, Giovanni, Montanucci, Ludovica, Turina, Paola, Capriotti, Emidio, Fariselli, Piero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397395/
https://www.ncbi.nlm.nih.gov/pubmed/32774791
http://dx.doi.org/10.1016/j.csbj.2020.07.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397395/
https://www.ncbi.nlm.nih.gov/pubmed/32774791
http://dx.doi.org/10.1016/j.csbj.2020.07.011

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