Cargando…

Protective Effect of Metformin against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial (RPE) Cells by Enhancing Autophagy through Activation of AMPK Pathway

Age-related macular degeneration (AMD) is a leading cause of blindness with limited effective treatment. Although the pathogenesis of this disease is complex and not fully understood, the oxidative damage caused by excessive reactive oxygen species (ROS) in retinal pigment epithelium (RPE) has been...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Xia, Liu, Linlin, Jiang, Yizhou, Silva, Marta, Zhen, Xuechu, Zheng, Wenhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397438/ https://www.ncbi.nlm.nih.gov/pubmed/32774666 http://dx.doi.org/10.1155/2020/2524174

Ejemplares similares

Berberine Protects Human Retinal Pigment Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Damage through Activation of AMPK
por: Li, Shuai, et al.
Publicado: (2018)

Protective Mechanism of Berberine on Human Retinal Pigment Epithelial Cells against Apoptosis Induced by Hydrogen Peroxide via the Stimulation of Autophagy
por: Li, Shuai, et al.
Publicado: (2021)

Ultraviolet (UV) and Hydrogen Peroxide Activate Ceramide-ER Stress-AMPK Signaling Axis to Promote Retinal Pigment Epithelium (RPE) Cell Apoptosis
por: Yao, Jin, et al.
Publicado: (2013)

Artemisinin protects human retinal pigment epithelial cells from hydrogen peroxide-induced oxidative damage through activation of ERK/CREB signaling
por: Chong, Cheong-Meng, et al.
Publicado: (2016)

Effects of melatonin and its receptor antagonist on retinal pigment epithelial cells against hydrogen peroxide damage
por: Rosen, Richard B., et al.
Publicado: (2012)

Artemisinin Protects Human Retinal Pigmented Epithelial Cells Against Hydrogen Peroxide-induced Oxidative Damage by Enhancing the Activation of AMP-active Protein Kinase
por: Li, Shuai, et al.
Publicado: (2019)

Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions
por: Bhattarai, Niina, et al.
Publicado: (2022)

Subtoxic levels hydrogen peroxide-induced production of interleukin-6 by retinal pigment epithelial cells
por: Wu, Wen-Chuan, et al.
Publicado: (2010)

Transcriptome-Wide Analysis of CXCR5 Deficient Retinal Pigment Epithelial (RPE) Cells Reveals Molecular Signatures of RPE Homeostasis
por: Saddala, Madhu Sudhana, et al.
Publicado: (2020)

Evaluation for Retinal Therapy for RPE65 Variation Assessed in hiPSC Retinal Pigment Epithelial Cells
por: Nash, Benjamin M., et al.
Publicado: (2021)

Scutellarin protects human retinal pigment epithelial cells against hydrogen peroxide (H(2)O(2))-induced oxidative damage
por: Hu, Xin, et al.
Publicado: (2019)

Age-Related Changes in the Retinal Pigment Epithelium (RPE)
por: Gu, Xiaorong, et al.
Publicado: (2012)

Proteomics of Human Retinal Pigment Epithelium (RPE) Cells
por: Beranova-Giorgianni, Sarka, et al.
Publicado: (2018)

Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors
por: Brown, Emily E., et al.
Publicado: (2019)

Citrulline protects human retinal pigment epithelium from hydrogen peroxide and iron/ascorbate induced damages
por: Hassel, Chervin, et al.
Publicado: (2022)

A Method for the Isolation and Culture of Adult Rat Retinal Pigment Epithelial (RPE) Cells to Study Retinal Diseases
por: Heller, Janosch P., et al.
Publicado: (2015)

Selective Ablation of Dehydrodolichyl Diphosphate Synthase in Murine Retinal Pigment Epithelium (RPE) Causes RPE Atrophy and Retinal Degeneration
por: DeRamus, Marci L., et al.
Publicado: (2020)

The transcriptome profile of RPE cells by the fullerenol against hydrogen peroxide stress
por: Wu, Xiaojun, et al.
Publicado: (2022)

Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA
por: Wu, Anthony Yan-Tang, et al.
Publicado: (2023)

Effects of Resvega on Inflammasome Activation in Conjunction with Dysfunctional Intracellular Clearance in Retinal Pigment Epithelial (RPE) Cells
por: Bhattarai, Niina, et al.
Publicado: (2021)

TNFα induced by DNA-sensing in macrophage compromises retinal pigment epithelial (RPE) barrier function
por: Twarog, Michael, et al.
Publicado: (2023)

Homer1a Attenuates Hydrogen Peroxide-Induced Oxidative Damage in HT-22 Cells through AMPK-Dependent Autophagy
por: Wu, Xiuquan, et al.
Publicado: (2018)

Pueraria lobata Extract Protects Hydrogen Peroxide-Induced Human Retinal Pigment Epithelial Cells Death and Membrane Permeability
por: Kang, Nu Ri, et al.
Publicado: (2019)

Sericin-Induced Melanogenesis in Cultured Retinal Pigment Epithelial Cells Is Associated with Elevated Levels of Hydrogen Peroxide and Inflammatory Proteins
por: Khan, Ayyad Zartasht, et al.
Publicado: (2020)

Nanoscopic Approach to Study the Early Stages of Epithelial to Mesenchymal Transition (EMT) of Human Retinal Pigment Epithelial (RPE) Cells In Vitro
por: Chtcheglova, Lilia A., et al.
Publicado: (2020)

Farrerol Enhances Nrf2-Mediated Defense Mechanisms against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial Cells by Activating Akt and MAPK
por: Ma, Ning, et al.
Publicado: (2021)

DJ-1-Dependent Regulation of Oxidative Stress in the Retinal Pigment Epithelium (RPE)
por: Shadrach, Karen G., et al.
Publicado: (2013)

Acadesine suppresses TNF-α induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells
por: Efstathiou, Nikolaos E., et al.
Publicado: (2020)

Cadherins in the retinal pigment epithelium (RPE) revisited: P-cadherin is the highly dominant cadherin expressed in human and mouse RPE in vivo
por: Yang, Xue, et al.
Publicado: (2018)

Hydrogen Sulfide Protects Retinal Pigment Epithelial Cells from Oxidative Stress-Induced Apoptosis and Affects Autophagy
por: Hu, Liming, et al.
Publicado: (2020)

Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E
por: Saadat, Khandakar A.S.M., et al.
Publicado: (2014)

Hydrogen peroxide and extracellular signal-related kinase 1/2 pathway regulate ferritin levels in retinal pigmented and lens epithelial cells
por: Lall, Marilyn M., et al.
Publicado: (2013)

Hydrogen peroxide-induced oxidative damage and protective role of peroxiredoxin 6 protein via EGFR/ERK signaling pathway in RPE cells
por: Chen, Xiaodong, et al.
Publicado: (2023)

Cellular and Molecular Preconditions for Retinal Pigment Epithelium (RPE) Natural Reprogramming during Retinal Regeneration in Urodela
por: Grigoryan, Eleonora N., et al.
Publicado: (2016)

Mechanism of Nucleic Acid Sensing in Retinal Pigment Epithelium (RPE): RIG-I Mediates Type I Interferon Response in Human RPE
por: Schustak, Joshua, et al.
Publicado: (2021)

Transplantation of human embryonic stem cell-derived retinal pigment epithelial cells (MA09-hRPE) in macular degeneration
por: Qiu, Tina Guanting
Publicado: (2019)

Lentiviral mediated RPE65 gene transfer in healthy hiPSCs-derived retinal pigment epithelial cells markedly increased RPE65 mRNA, but modestly protein level
por: Udry, Florian, et al.
Publicado: (2020)

Correction: DJ-1-Dependent Regulation of Oxidative Stress in the Retinal Pigment Epithelium (RPE)
Publicado: (2014)

Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE)
por: Giannaccini, Martina, et al.
Publicado: (2014)

Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE) Underlies Irreversible Blinding Diseases
por: Keeling, Eloise, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_nnbjgpnadq1e4pnamh9ua2ctkj