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Distinct modes of action of CD40L and adaptive cytokines IL-2, IL-4/13, IL-10 and IL-21 on rainbow trout IgM(+) B cells

In mammals, conventional B (B2) cells are activated within lymphoid follicles through a close relationship with T follicular helper (Tfh) cells. The interaction between CD40 expressed on B cells and its ligand (CD40L) expressed on Tfh cells is a key signal that regulates the formation of germinal ce...

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Detalles Bibliográficos
Autores principales: Abos, Beatriz, Wang, Tiehui, Secombes, Christopher J., Tafalla, Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397517/
https://www.ncbi.nlm.nih.gov/pubmed/32447012
http://dx.doi.org/10.1016/j.dci.2020.103752