Hypomethylation in HBV integration regions aids non-invasive surveillance to hepatocellular carcinoma by low-pass genome-wide bisulfite sequencing

BACKGROUND: Circulating cell-free DNA (cfDNA) methylation has been demonstrated to be a promising approach for non-invasive cancer diagnosis. However, the high cost of whole genome bisulfite sequencing (WGBS) hinders the clinical implementation of a methylation-based cfDNA early detection biomarker....

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Detalles Bibliográficos
Autores principales: Zhang, Haikun, Dong, Peiling, Guo, Shicheng, Tao, Chengcheng, Chen, Wei, Zhao, Wenmin, Wang, Jiakang, Cheung, Ramsey, Villanueva, Augusto, Fan, Jian, Ding, Huiguo, Schrodi, Steven J., Zhang, Dake, Zeng, Changqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397586/
https://www.ncbi.nlm.nih.gov/pubmed/32741373
http://dx.doi.org/10.1186/s12916-020-01667-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397586/
https://www.ncbi.nlm.nih.gov/pubmed/32741373
http://dx.doi.org/10.1186/s12916-020-01667-x

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