Insulator-based loops mediate the spreading of H3K27me3 over distant micro-domains repressing euchromatin genes

BACKGROUND: Chromosomes are subdivided spatially to delimit long-range interactions into topologically associating domains (TADs). TADs are often flanked by chromatin insulators and transcription units that may participate in such demarcation. Remarkably, single-cell Drosophila TAD units correspond...

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Detalles Bibliográficos
Autores principales: Heurteau, Alexandre, Perrois, Charlène, Depierre, David, Fosseprez, Olivier, Humbert, Jonathan, Schaak, Stéphane, Cuvier, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397589/
https://www.ncbi.nlm.nih.gov/pubmed/32746892
http://dx.doi.org/10.1186/s13059-020-02106-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397589/
https://www.ncbi.nlm.nih.gov/pubmed/32746892
http://dx.doi.org/10.1186/s13059-020-02106-z

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