Fumarate hydratase-deficient renal cell carcinoma cells respond to asparagine by activation of the unfolded protein response and stimulation of the hexosamine biosynthetic pathway

BACKGROUND: The loss-of-function mutation of fumarate hydratase (FH) is a driver of hereditary leiomyomatosis and renal cell carcinoma (HLRCC). Fumarate accumulation results in activation of stress-related mechanisms leading to upregulation of cell survival-related genes. To better understand how ce...

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Detalles Bibliográficos
Autores principales: Panarsky, Rony, Crooks, Daniel R., Lane, Andrew N., Yang, Youfeng, Cassel, Teresa A., Fan, Teresa W.-M., Linehan, W. Marston, Moscow, Jeffrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397616/
https://www.ncbi.nlm.nih.gov/pubmed/32774853
http://dx.doi.org/10.1186/s40170-020-00214-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397616/
https://www.ncbi.nlm.nih.gov/pubmed/32774853
http://dx.doi.org/10.1186/s40170-020-00214-9

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