Crystal structure of human lysosomal acid lipase and its implications in cholesteryl ester storage disease

Lysosomal acid lipase (LAL) is a serine hydrolase that hydrolyzes cholesteryl ester (CE) and TGs delivered to the lysosomes into free cholesterol and fatty acids. LAL deficiency due to mutations in the LAL gene (LIPA) results in accumulation of TGs and cholesterol esters in various tissues of the bo...

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Detalles Bibliográficos
Autores principales: Rajamohan, Francis, Reyes, Allan R., Tu, Meihua, Nedoma, Nicole L., Hoth, Lise R., Schwaid, Adam G., Kurumbail, Ravi G., Ward, Jessica, Han, Seungil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397744/
https://www.ncbi.nlm.nih.gov/pubmed/32482718
http://dx.doi.org/10.1194/jlr.RA120000748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397744/
https://www.ncbi.nlm.nih.gov/pubmed/32482718
http://dx.doi.org/10.1194/jlr.RA120000748

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