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A role for alternative splicing in circadian control of exocytosis and glucose homeostasis

The circadian clock is encoded by a negative transcriptional feedback loop that coordinates physiology and behavior through molecular programs that remain incompletely understood. Here, we reveal rhythmic genome-wide alternative splicing (AS) of pre-mRNAs encoding regulators of peptidergic secretion...

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Detalles Bibliográficos
Autores principales: Marcheva, Biliana, Perelis, Mark, Weidemann, Benjamin J., Taguchi, Akihiko, Lin, Haopeng, Omura, Chiaki, Kobayashi, Yumiko, Newman, Marsha V., Wyatt, Eugene J., McNally, Elizabeth M., Fox, Jocelyn E. Manning, Hong, Heekyung, Shankar, Archana, Wheeler, Emily C., Ramsey, Kathryn Moynihan, MacDonald, Patrick E., Yeo, Gene W., Bass, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397853/
https://www.ncbi.nlm.nih.gov/pubmed/32616519
http://dx.doi.org/10.1101/gad.338178.120