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Translation initiation downstream from annotated start codons in human mRNAs coevolves with the Kozak context

Eukaryotic translation initiation involves preinitiation ribosomal complex 5′-to-3′ directional probing of mRNA for codons suitable for starting protein synthesis. The recognition of codons as starts depends on the codon identity and on its immediate nucleotide context known as Kozak context. When t...

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Detalles Bibliográficos
Autores principales: Benitez-Cantos, Maria S., Yordanova, Martina M., O'Connor, Patrick B.F., Zhdanov, Alexander V., Kovalchuk, Sergey I., Papkovsky, Dmitri B., Andreev, Dmitry E., Baranov, Pavel V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397870/
https://www.ncbi.nlm.nih.gov/pubmed/32669370
http://dx.doi.org/10.1101/gr.257352.119