Talin1 sets the stage for dendritic cell activation

In this issue of JEM, Lim et al. (https://doi.org/10.1084/jem.20191810) provide exciting new evidence that talin1 plays an essential role in dendritic cell (DC) maturation and activation. Using conditional knockout mice, they demonstrate that talin1 promotes the formation of a preassembled TLR–Myddo...

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Detalles Bibliográficos
Autor principal: Clausen, Björn E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398172/
https://www.ncbi.nlm.nih.gov/pubmed/32697285
http://dx.doi.org/10.1084/jem.20200574
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author Clausen, Björn E.
author_facet Clausen, Björn E.
author_sort Clausen, Björn E.
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description In this issue of JEM, Lim et al. (https://doi.org/10.1084/jem.20191810) provide exciting new evidence that talin1 plays an essential role in dendritic cell (DC) maturation and activation. Using conditional knockout mice, they demonstrate that talin1 promotes the formation of a preassembled TLR–Myddosome signaling complex in steady-state DCs but not macrophages. This may explain why DCs respond faster and more vigorously to TLR ligand binding than their closely related macrophages.
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spelling pubmed-73981722021-02-03 Talin1 sets the stage for dendritic cell activation Clausen, Björn E. J Exp Med Insights In this issue of JEM, Lim et al. (https://doi.org/10.1084/jem.20191810) provide exciting new evidence that talin1 plays an essential role in dendritic cell (DC) maturation and activation. Using conditional knockout mice, they demonstrate that talin1 promotes the formation of a preassembled TLR–Myddosome signaling complex in steady-state DCs but not macrophages. This may explain why DCs respond faster and more vigorously to TLR ligand binding than their closely related macrophages. Rockefeller University Press 2020-07-22 /pmc/articles/PMC7398172/ /pubmed/32697285 http://dx.doi.org/10.1084/jem.20200574 Text en © 2020 Clausen http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Clausen, Björn E.
Talin1 sets the stage for dendritic cell activation
title Talin1 sets the stage for dendritic cell activation
title_full Talin1 sets the stage for dendritic cell activation
title_fullStr Talin1 sets the stage for dendritic cell activation
title_full_unstemmed Talin1 sets the stage for dendritic cell activation
title_short Talin1 sets the stage for dendritic cell activation
title_sort talin1 sets the stage for dendritic cell activation
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398172/
https://www.ncbi.nlm.nih.gov/pubmed/32697285
http://dx.doi.org/10.1084/jem.20200574
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