Synaptic restoration by cAMP/PKA drives activity-dependent neuroprotection to motoneurons in ALS

Excessive excitation is hypothesized to cause motoneuron (MN) degeneration in amyotrophic lateral sclerosis (ALS), but actual proof of hyperexcitation in vivo is missing, and trials based on this concept have failed. We demonstrate, by in vivo single-MN electrophysiology, that, contrary to expectati...

Descripción completa

Detalles Bibliográficos
Autores principales: Bączyk, Marcin, Alami, Najwa Ouali, Delestrée, Nicolas, Martinot, Clémence, Tang, Linyun, Commisso, Barbara, Bayer, David, Doisne, Nicolas, Frankel, Wayne, Manuel, Marin, Roselli, Francesco, Zytnicki, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398175/
https://www.ncbi.nlm.nih.gov/pubmed/32484501
http://dx.doi.org/10.1084/jem.20191734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398175/
https://www.ncbi.nlm.nih.gov/pubmed/32484501
http://dx.doi.org/10.1084/jem.20191734

Ejemplares similares