A highly processive actinobacterial topoisomerase I – thoughts on Streptomyces’ demand for an enzyme with a unique C-terminal domain

Topoisomerase I (TopA) is an essential enzyme that is required to remove excess negative supercoils from chromosomal DNA. Actinobacteria encode unusual TopA homologues with a unique C-terminal domain that contains lysine repeats and confers high enzyme processivity. Interestingly, the longest stretc...

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Detalles Bibliográficos
Autores principales: Szafran, Marcin J., Strzałka, Agnieszka, Jakimowicz, Dagmara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398561/
https://www.ncbi.nlm.nih.gov/pubmed/31390324
http://dx.doi.org/10.1099/mic.0.000841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398561/
https://www.ncbi.nlm.nih.gov/pubmed/31390324
http://dx.doi.org/10.1099/mic.0.000841

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