Periconceptional exposure to lopinavir, but not darunavir, impairs decidualization: a potential mechanism leading to poor birth outcomes in HIV-positive pregnancies

STUDY QUESTION: Does HIV protease inhibitor (PI)-based combination antiretroviral therapy (cART) initiated at periconception affect key events in early pregnancy, i.e. decidualization and spiral artery remodeling? SUMMARY ANSWER: Two PIs, lopinavir and darunavir, currently offered as cART options in...

Descripción completa

Detalles Bibliográficos
Autores principales: Kala, Smriti, Dunk, Caroline, Acosta, Sebastian, Serghides, Lena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398624/
https://www.ncbi.nlm.nih.gov/pubmed/32712670
http://dx.doi.org/10.1093/humrep/deaa151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398624/
https://www.ncbi.nlm.nih.gov/pubmed/32712670
http://dx.doi.org/10.1093/humrep/deaa151

Ejemplares similares