PARP1 Impedes SIRT1-Mediated Autophagy during Degeneration of the Retinal Pigment Epithelium under Oxidative Stress

The molecular mechanism underlying autophagy impairment in the retinal pigment epithelium (RPE) in dry age-related macular degeneration (AMD) is not yet clear. Based on the causative role of poly(ADP-ribose) polymerase 1 (PARP1) in RPE necrosis, this study examined whether PARP1 is involved in the a...

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Detalles Bibliográficos
Autores principales: Jang, Ki-Hong, Hwang, Yeseong, Kim, Eunhee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398797/
https://www.ncbi.nlm.nih.gov/pubmed/32732457
http://dx.doi.org/10.14348/molcells.2020.0078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398797/
https://www.ncbi.nlm.nih.gov/pubmed/32732457
http://dx.doi.org/10.14348/molcells.2020.0078

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