Cargando…

PARP1 Impedes SIRT1-Mediated Autophagy during Degeneration of the Retinal Pigment Epithelium under Oxidative Stress

The molecular mechanism underlying autophagy impairment in the retinal pigment epithelium (RPE) in dry age-related macular degeneration (AMD) is not yet clear. Based on the causative role of poly(ADP-ribose) polymerase 1 (PARP1) in RPE necrosis, this study examined whether PARP1 is involved in the a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jang, Ki-Hong, Hwang, Yeseong, Kim, Eunhee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Molecular and Cellular Biology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398797/ https://www.ncbi.nlm.nih.gov/pubmed/32732457 http://dx.doi.org/10.14348/molcells.2020.0078

Ejemplares similares

Autophagy regulates death of retinal pigment epithelium cells in age-related macular degeneration
por: Kaarniranta, Kai, et al.
Publicado: (2016)

The many faces of SIRT6 in the retina and retinal pigment epithelium
por: Cheng, Jie, et al.
Publicado: (2023)

Involvement of the Retinal Pigment Epithelium in the Development of Retinal Lattice Degeneration
por: Mizuno, Hiroshi, et al.
Publicado: (2020)

Abnormal mTORC1 signaling leads to retinal pigment epithelium degeneration
por: Huang, Jiancheng, et al.
Publicado: (2019)

Prominin-1 Is a Novel Regulator of Autophagy in the Human Retinal Pigment Epithelium
por: Bhattacharya, Sujoy, et al.
Publicado: (2017)

Spermidine Oxidation-Mediated Degeneration of Retinal Pigment Epithelium in Rats
por: Ohashi, Koji, et al.
Publicado: (2017)

Tracking the Transplanted Neurosphere in Retinal Pigment Epithelium Degeneration Model
por: Kadkhodaeian, Hamid Aboutaleb, et al.
Publicado: (2021)

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration
por: Kaarniranta, Kai, et al.
Publicado: (2013)

Inhibition of DUSP6 Activates Autophagy and Rescues the Retinal Pigment Epithelium in Sodium Iodate-Induced Retinal Degeneration Models In Vivo and In Vitro
por: Tsai, Hao-Yu, et al.
Publicado: (2022)

Autophagy and Exosomes in the Aged Retinal Pigment Epithelium: Possible Relevance to Drusen Formation and Age-Related Macular Degeneration
por: Wang, Ai Ling, et al.
Publicado: (2009)

Investigating mitochondrial fission, fusion, and autophagy in retinal pigment epithelium from donors with age-related macular degeneration
por: Fisher, Cody R., et al.
Publicado: (2022)

Retinoid Metabolism in the Degeneration of Pten-Deficient Mouse Retinal Pigment Epithelium
por: Kim, You-Joung, et al.
Publicado: (2021)

HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration
por: Tang, Zhimin, et al.
Publicado: (2021)

Vitamin C Protected Human Retinal Pigmented Epithelium from Oxidant Injury Depending on Regulating SIRT1
por: Wei, Wei, et al.
Publicado: (2014)

Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration
por: Storti, Federica, et al.
Publicado: (2019)

Sulforaphane ameliorates amyloid-β-induced inflammatory injury by suppressing the PARP1/SIRT1 pathway in retinal pigment epithelial cells
por: Wang, Song, et al.
Publicado: (2022)

Autophagy resists EMT process to maintain retinal pigment epithelium homeostasis
por: Feng, Hao, et al.
Publicado: (2019)

Autophagy in the retinal pigment epithelium: a new vision and future challenges
por: Intartaglia, Daniela, et al.
Publicado: (2021)

Hormetic Heat Shock Enhances Autophagy through HSF1 in Retinal Pigment Epithelium Cells
por: Amirkavei, Mooud, et al.
Publicado: (2022)

NLRP3 Upregulation in Retinal Pigment Epithelium in Age-Related Macular Degeneration
por: Wang, Yujuan, et al.
Publicado: (2016)

Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration
por: Kim, Jongmin, et al.
Publicado: (2021)

Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration
por: Senabouth, Anne, et al.
Publicado: (2022)

Dissecting Regulators of Aging and Age-Related Macular Degeneration in the Retinal Pigment Epithelium
por: Karunadharma, Pabalu P., et al.
Publicado: (2022)

Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment in age-related macular degeneration
por: Miura, Masahiro, et al.
Publicado: (2021)

SIRT6 overexpression in the nucleus protects mouse retinal pigment epithelium from oxidative stress
por: Yang, Xue, et al.
Publicado: (2023)

Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA
por: Wu, Anthony Yan-Tang, et al.
Publicado: (2023)

Evaluation of focal damage in the retinal pigment epithelium layer in serous retinal pigment epithelium detachment
por: Miura, Masahiro, et al.
Publicado: (2019)

Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration
por: Pyakurel, Aswin, et al.
Publicado: (2017)

Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium
por: Toops, Kimberly A., et al.
Publicado: (2015)

Novel Localization of Peripherin 2, the Photoreceptor-Specific Retinal Degeneration Slow Protein, in Retinal Pigment Epithelium
por: Uhl, Patrizia B., et al.
Publicado: (2015)

Human Amniotic Epithelial Stem Cell-Derived Retinal Pigment Epithelium Cells Repair Retinal Degeneration
por: Li, Jinying, et al.
Publicado: (2021)

Erythropoietin Gene Therapy Delays Retinal Degeneration Resulting from Oxidative Stress in the Retinal Pigment Epithelium
por: Biswal, Manas R., et al.
Publicado: (2021)

Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa
por: Mercau, Maria E., et al.
Publicado: (2023)

Translocation of the retinal pigment epithelium and formation of sub-retinal pigment epithelium deposit induced by subretinal deposit
por: Zhao, Lian, et al.
Publicado: (2007)

Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration
por: Lenis, Tamara L., et al.
Publicado: (2018)

Concise Review: Update on Retinal Pigment Epithelium Transplantation for Age‐Related Macular Degeneration
por: Zarbin, Marco, et al.
Publicado: (2019)

The Cytoskeleton of the Retinal Pigment Epithelium: from Normal Aging to Age-Related Macular Degeneration
por: Tarau, Ioana-Sandra, et al.
Publicado: (2019)

Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration
por: Voigt, Andrew P., et al.
Publicado: (2019)

Sub-retinal pigment epithelium tubules in non-neovascular age-related macular degeneration
por: Fragiotta, Serena, et al.
Publicado: (2022)

Impaired lysosomes in the retinal pigment epithelium play a central role in the degeneration of the neuroretina
por: Miller, Rebecca D., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_4damokdqf8tvmre2qab6j373h5