Spatiotemporal Gradient and Instability of Wnt Induce Heterogeneous Growth and Differentiation of Human Intestinal Organoids

In a conventional culture of three-dimensional human intestinal organoids, extracellular matrix hydrogel has been used to provide a physical space for the growth and morphogenesis of organoids in the presence of exogenous morphogens such as Wnt3a. We found that organoids embedded in a dome-shaped hy...

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Detalles Bibliográficos
Autores principales: Shin, Woojung, Wu, Alexander, Min, Soyoun, Shin, Yong Cheol, Fleming, R. Y. Declan, Eckhardt, S. Gail, Kim, Hyun Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398973/
https://www.ncbi.nlm.nih.gov/pubmed/32745985
http://dx.doi.org/10.1016/j.isci.2020.101372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398973/
https://www.ncbi.nlm.nih.gov/pubmed/32745985
http://dx.doi.org/10.1016/j.isci.2020.101372

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