Successful application of anti-CD19 CAR-T therapy with IL-6 knocking down to patients with central nervous system B-cell acute lymphocytic leukemia

Few studies have described chimeric antigen receptor–modified T cell (CAR-T) therapy for central nervous system (CNS) B-cell acute lymphocytic leukemia (B-ALL) patients due to life-threatening CAR-T-related encephalopathy (CRES) safety issues. In this study, CAR-Ts targeting CD19 with short hairpin...

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Detalles Bibliográficos
Autores principales: Chen, Li-Yun, Kang, Li-Qing, Zhou, Hai-Xia, Gao, Han-Qing, Zhu, Xue-Fei, Xu, Nan, Yu, Lei, Wu, De-Pei, Xue, Sheng-Li, Sun, Ai-Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399187/
https://www.ncbi.nlm.nih.gov/pubmed/32745961
http://dx.doi.org/10.1016/j.tranon.2020.100838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399187/
https://www.ncbi.nlm.nih.gov/pubmed/32745961
http://dx.doi.org/10.1016/j.tranon.2020.100838

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