Heme Synthesis Inhibition Blocks Angiogenesis via Mitochondrial Dysfunction

The relationship between heme metabolism and angiogenesis is poorly understood. The final synthesis of heme occurs in mitochondria, where ferrochelatase (FECH) inserts Fe(2+) into protoporphyrin IX to produce proto-heme IX. We previously showed that FECH inhibition is antiangiogenic in human retinal...

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Detalles Bibliográficos
Autores principales: Shetty, Trupti, Sishtla, Kamakshi, Park, Bomina, Repass, Matthew J., Corson, Timothy W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399258/
https://www.ncbi.nlm.nih.gov/pubmed/32755804
http://dx.doi.org/10.1016/j.isci.2020.101391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399258/
https://www.ncbi.nlm.nih.gov/pubmed/32755804
http://dx.doi.org/10.1016/j.isci.2020.101391

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