Cargando…

Heme Synthesis Inhibition Blocks Angiogenesis via Mitochondrial Dysfunction

The relationship between heme metabolism and angiogenesis is poorly understood. The final synthesis of heme occurs in mitochondria, where ferrochelatase (FECH) inserts Fe(2+) into protoporphyrin IX to produce proto-heme IX. We previously showed that FECH inhibition is antiangiogenic in human retinal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shetty, Trupti, Sishtla, Kamakshi, Park, Bomina, Repass, Matthew J., Corson, Timothy W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399258/ https://www.ncbi.nlm.nih.gov/pubmed/32755804 http://dx.doi.org/10.1016/j.isci.2020.101391

Ejemplares similares

Mitochondrial Heme Synthesis Enzymes as Therapeutic Targets in Vascular Diseases
por: Shetty, Trupti, et al.
Publicado: (2020)

Measurement of mitochondrial respiration in the murine retina using a Seahorse extracellular flux analyzer
por: Shetty, Trupti, et al.
Publicado: (2021)

An improved method for murine laser-induced choroidal neovascularization lesion quantification from optical coherence tomography images
por: Jensen, Nathan R., et al.
Publicado: (2022)

Decreased Expression of Soluble Epoxide Hydrolase Suppresses Murine Choroidal Neovascularization
por: Park, Bomina, et al.
Publicado: (2022)

Retinal Phenotyping of Ferrochelatase Mutant Mice Reveals Protoporphyrin Accumulation and Reduced Neovascular Response
por: Sardar Pasha, S. P. B., et al.
Publicado: (2021)

Soluble Epoxide Hydrolase Inhibition for Ocular Diseases: Vision for the Future
por: Park, Bomina, et al.
Publicado: (2019)

Identification of Novel Pathways Regulated by APE1/Ref-1 in Human Retinal Endothelial Cells
por: Mijit, Mahmut, et al.
Publicado: (2023)

Calcitriol and non-calcemic vitamin D analogue, 22-oxacalcitriol, attenuate developmental and pathological choroidal vasculature angiogenesis ex vivo and in vivo
por: Merrigan, Stephanie L., et al.
Publicado: (2020)

Pharmacological Potential of Small Molecules for Treating Corneal Neovascularization
por: Barry, Zachary, et al.
Publicado: (2020)

PRMT5 is a therapeutic target in choroidal neovascularization
por: Muniyandi, Anbukkarasi, et al.
Publicado: (2023)

Ferrochelatase is a therapeutic target for ocular neovascularization
por: Basavarajappa, Halesha D, et al.
Publicado: (2017)

Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14
por: Sishtla, Kamakshi, et al.
Publicado: (2018)

Regulation of Heme Synthesis by Mitochondrial Homeostasis Proteins
por: Yien, Yvette Y., et al.
Publicado: (2022)

Flutamide Induces Hepatic Cell Death and Mitochondrial Dysfunction via Inhibition of Nrf2-Mediated Heme Oxygenase-1
por: Zhang, Li, et al.
Publicado: (2018)

From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme
por: Swenson, Samantha A., et al.
Publicado: (2020)

Neuroprotective potential of escitalopram against behavioral, mitochondrial and oxidative dysfunction induced by 3-nitropropionic acid
por: Shetty, Shruthi, et al.
Publicado: (2015)

Mitochondrial Atpif1 regulates heme synthesis in developing erythroblasts
por: Shah, Dhvanit I., et al.
Publicado: (2012)

The ubiquitous mitochondrial protein unfoldase CLPX regulates erythroid heme synthesis by control of iron utilization and heme synthesis enzyme activation and turnover
por: Rondelli, Catherine M., et al.
Publicado: (2021)

MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme
por: Li, Yingzhong, et al.
Publicado: (2020)

Brevilin A Inhibits VEGF-Induced Angiogenesis through ROS-Dependent Mitochondrial Dysfunction
por: Wei, Bailing, et al.
Publicado: (2022)

Patient preferences in retinal drug delivery
por: Jacobs, Brandon, et al.
Publicado: (2021)

Inhibition of Heme Export and/or Heme Synthesis Potentiates Metformin Anti-Proliferative Effect on Cancer Cell Lines
por: Allocco, Anna Lucia, et al.
Publicado: (2022)

Kalkitoxin Inhibits Angiogenesis, Disrupts Cellular Hypoxic Signaling, and Blocks Mitochondrial Electron Transport in Tumor Cells
por: Morgan, J. Brian, et al.
Publicado: (2015)

Sinularin Induces Oxidative Stress-Mediated Apoptosis and Mitochondrial Dysfunction, and Inhibits Angiogenesis in Glioblastoma Cells
por: Hsu, Shih-Yuan, et al.
Publicado: (2022)

Tigecycline as a dual inhibitor of retinoblastoma and angiogenesis via inducing mitochondrial dysfunctions and oxidative damage
por: Xiong, Ying, et al.
Publicado: (2018)

Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis
por: Petrillo, Sara, et al.
Publicado: (2017)

NF-κB Signaling Is Regulated by Fucosylation in Metastatic Breast Cancer Cells
por: Doud, Emma H., et al.
Publicado: (2020)

Identification of the Mitochondrial Heme Metabolism Complex
por: Medlock, Amy E., et al.
Publicado: (2015)

Blocking heme oxygenase-1 by zinc protoporphyrin reduces tumor hypoxia-mediated VEGF release and inhibits tumor angiogenesis as a potential therapeutic agent against colorectal cancer
por: Cheng, Chun-Chia, et al.
Publicado: (2016)

Stromal cell–derived factor 1 promotes angiogenesis via a heme oxygenase 1–dependent mechanism
por: Deshane, Jessy, et al.
Publicado: (2007)

Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization
por: Cunnington, A. J., et al.
Publicado: (2011)

Mitochondrial Targeting in Neurodegeneration: A Heme Perspective
por: Fiorito, Veronica, et al.
Publicado: (2018)

Nascent Synthesis of Leader Sequence-Containing Subgenomic mRNAs in Coronavirus Genome-Length Replicative Intermediate RNA
por: Mizutani, Tetsuya, et al.
Publicado: (2000)

The immunometabolite itaconate inhibits heme synthesis and remodels cellular metabolism in erythroid precursors
por: Marcero, Jason R., et al.
Publicado: (2021)

New Avenues of Heme Synthesis Regulation
por: Medlock, Amy E., et al.
Publicado: (2022)

Inhibition of Heme Peroxidases by Melamine
por: Vanachayangkul, Pattaraporn, et al.
Publicado: (2012)

Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking
por: Lyu, Junfang, et al.
Publicado: (2018)

Vildagliptin improves high glucose‐induced endothelial mitochondrial dysfunction via inhibiting mitochondrial fission
por: Liu, Hengdao, et al.
Publicado: (2018)

Optimized protocol for quantification of mitochondrial non-heme and heme iron content in mouse tissues and cultured cells
por: Sato, Tatsuya, et al.
Publicado: (2023)

Non-heme iron overload impairs monocyte to macrophage differentiation via mitochondrial oxidative stress
por: Cui, Yue, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1jb12q0b0rlmijdbssro1k7428