Prediction of the Impact of Deleterious Nonsynonymous Single Nucleotide Polymorphisms on the Human RRM2B Gene: A Molecular Modeling Study

RRM2B gene encodes ribonucleoside-diphosphate reductase subunit M2 B, the p53-inducible small subunit (p53R2) of ribonucleotide reductase (RNR), an enzyme catalyzing dNTP synthesis for mitochondrial DNA. Defects in this gene may cause severe mitochondrial disease affecting mainly the nervous system....

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Detalles Bibliográficos
Autores principales: Ait El Cadi, Chaimaa, Krami, Al Mehdi, Charoute, Hicham, Elkarhat, Zouhair, Sifeddine, Najat, Lakhiari, Hamid, Rouba, Hassan, Barakat, Abdelhamid, Nahili, Halima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399733/
https://www.ncbi.nlm.nih.gov/pubmed/32775440
http://dx.doi.org/10.1155/2020/7614634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399733/
https://www.ncbi.nlm.nih.gov/pubmed/32775440
http://dx.doi.org/10.1155/2020/7614634

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