Intrinsic Type 1 Interferon (IFN1) Profile of Uncultured Human Bone Marrow CD45(low)CD271(+) Multipotential Stromal Cells (BM-MSCs): The Impact of Donor Age, Culture Expansion and IFNα and IFNβ Stimulation

Skeletal aging is associated with reduced proliferative potential of bone marrow (BM) multipotential stromal cells (MSCs). Recent data suggest the involvement of type 1 interferon (IFN1) signalling in hematopoietic stem cell (HSC) senescence. Considering that BM-HSCs and BM-MSCs share the same BM ni...

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Detalles Bibliográficos
Autores principales: Ganguly, Payal, Burska, Agata N., Davis, Charlotte L.M., El-Jawhari, Jehan J., Giannoudis, Peter V., Jones, Elena A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399891/
https://www.ncbi.nlm.nih.gov/pubmed/32679782
http://dx.doi.org/10.3390/biomedicines8070214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399891/
https://www.ncbi.nlm.nih.gov/pubmed/32679782
http://dx.doi.org/10.3390/biomedicines8070214

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