xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma

Glutathione (GSH) is a primary antioxidant that protects cells against reactive oxygen species (ROS), and high levels of GSH promote cancer cell survival and resistance to chemotherapy. The glutamine transporter xCT is essential for the intracellular synthesis of GSH, whereby xCT determines the intr...

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Detalles Bibliográficos
Autores principales: Sugiyama, Akiko, Ohta, Tsuyoshi, Obata, Miyuki, Takahashi, Kanako, Seino, Manabu, Nagase, Satoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400102/
https://www.ncbi.nlm.nih.gov/pubmed/32782585
http://dx.doi.org/10.3892/ol.2020.11813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400102/
https://www.ncbi.nlm.nih.gov/pubmed/32782585
http://dx.doi.org/10.3892/ol.2020.11813

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