Cargando…

xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma

Glutathione (GSH) is a primary antioxidant that protects cells against reactive oxygen species (ROS), and high levels of GSH promote cancer cell survival and resistance to chemotherapy. The glutamine transporter xCT is essential for the intracellular synthesis of GSH, whereby xCT determines the intr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sugiyama, Akiko, Ohta, Tsuyoshi, Obata, Miyuki, Takahashi, Kanako, Seino, Manabu, Nagase, Satoru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400102/ https://www.ncbi.nlm.nih.gov/pubmed/32782585 http://dx.doi.org/10.3892/ol.2020.11813

Ejemplares similares

Metabolomic analysis of uterine serous carcinoma with acquired resistance to paclitaxel
por: Seino, Manabu, et al.
Publicado: (2018)

Impact of the glutathione synthesis pathway on sulfasalazine-treated endometrial cancer
por: Sendo, Kanako, et al.
Publicado: (2022)

Correction: Metabolomic analysis of uterine serous carcinoma with acquired resistance to paclitaxel
por: Seino, Manabu, et al.
Publicado: (2021)

Mechanism of Cell Death by Combined Treatment with an xCT Inhibitor and Paclitaxel: An Alternative Therapeutic Strategy for Patients with Ovarian Clear Cell Carcinoma
por: Idei, Urara, et al.
Publicado: (2023)

Sulfasalazine Sensitizes Polyhematoporphyrin-Mediated Photodynamic Therapy in Cholangiocarcinoma by Targeting xCT
por: Zheng, Yan-Wen, et al.
Publicado: (2021)

Squamous cell carcinoma arising from a mature cystic teratoma of the ovary: Successful treatment with carboplatin, paclitaxel, and bevacizumab
por: Fukase, Mika, et al.
Publicado: (2020)

Successful management of cutaneous lymphangitis carcinomatosa arising from cervical cancer with paclitaxel-cisplatin and bevacizumab combination therapy: a case report and review of the literature
por: Nakamura, Fumihiro, et al.
Publicado: (2019)

High expression of CD44v9 and xCT in chemoresistant hepatocellular carcinoma: Potential targets by sulfasalazine
por: Wada, Fumitaka, et al.
Publicado: (2018)

Sulfasalazine, a potent suppressor of gastric cancer proliferation and metastasis by inhibition of xCT: Conventional drug in new use
por: Zhuang, Jinfu, et al.
Publicado: (2021)

Sulfasalazine could modulate the CD44v9‐xCT system and enhance cisplatin‐induced cytotoxic effects in metastatic bladder cancer
por: Ogihara, Koichiro, et al.
Publicado: (2019)

Tumor lysis syndrome associated with docetaxel and carboplatin in a case with recurrent endometrial cancer
por: Ito, Tomomichi, et al.
Publicado: (2018)

A xCT role in tumour-associated ferroptosis shed light on novel therapeutic options
por: Criscuolo, Daniela, et al.
Publicado: (2022)

xCT-Driven Expression of GPX4 Determines Sensitivity of Breast Cancer Cells to Ferroptosis Inducers
por: Lee, Namgyu, et al.
Publicado: (2021)

Butyrate reverses ferroptosis resistance in colorectal cancer by inducing c-Fos-dependent xCT suppression
por: He, Ying, et al.
Publicado: (2023)

Comparative treatment of Sulfasalazine+Ezetimibe combination and Sulfasalazine in a rat model with induced colitis
por: Jaafar, Farrah Rasool, et al.
Publicado: (2023)

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner
por: Chen, D, et al.
Publicado: (2017)

Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis
por: Sehm, Tina, et al.
Publicado: (2016)

A Cystine-Cysteine Intercellular Shuttle Prevents Ferroptosis in xCT(KO) Pancreatic Ductal Adenocarcinoma Cells
por: Meira, Willian, et al.
Publicado: (2021)

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy
por: Koppula, Pranavi, et al.
Publicado: (2020)

Atorvastatin Induces Mitochondria-Dependent Ferroptosis via the Modulation of Nrf2-xCT/GPx4 Axis
por: Zhang, Qi, et al.
Publicado: (2022)

STEAP3 Affects Ferroptosis and Progression of Renal Cell Carcinoma Through the p53/xCT Pathway
por: Ye, Cheng Lin, et al.
Publicado: (2022)

Inhibition of LSD1 induces ferroptosis through the ATF4-xCT pathway and shows enhanced anti-tumor effects with ferroptosis inducers in NSCLC
por: Du, Linna, et al.
Publicado: (2023)

Impact of adjuvant chemotherapy on the overall survival of patients with resectable bulky small cell neuroendocrine cervical cancer: a JSGO-JSOG joint study
por: Seino, Manabu, et al.
Publicado: (2022)

Ophiopogonin B induces gastric cancer cell death by blocking the GPX4/xCT-dependent ferroptosis pathway
por: Zhang, Liyi, et al.
Publicado: (2022)

d-Cysteine supplementation partially protects against ferroptosis induced by xCT dysfunction via increasing the availability of glutathione
por: Homma, Takujiro, et al.
Publicado: (2022)

AdipoR1 Regulates Ionizing Radiation-Induced Ferroptosis in HCC cells through Nrf2/xCT Pathway
por: Feng, Hao, et al.
Publicado: (2022)

Bilateral Transient Myopia with Sulfasalazine Treatment
por: Paz, Tal, et al.
Publicado: (2019)

Sulfasalazine decreases mouse cortical hyperexcitability
por: Alcoreza, Oscar, et al.
Publicado: (2019)

Sulfasalazine: DRESS syndrome: case report
Publicado: (2021)

Sulfasalazine: DRESS syndrome: case report
Publicado: (2021)

Case report: Sulfasalazine-induced hypersensitivity
por: Kuchinskaya, Ekaterina M., et al.
Publicado: (2023)

Advanced papillary serous carcinoma of the uterine cervix: a case with a remarkable response to paclitaxel and carboplatin combination chemotherapy
por: Ueda, Masashi, et al.
Publicado: (2011)

The structure of erastin-bound xCT–4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis
por: Yan, Renhong, et al.
Publicado: (2022)

Usefulness of sulfasalazine for patients with refractory-ulcerative colits
por: Yoshino, Takuya, et al.
Publicado: (2016)

Sulfasalazine induces mitochondrial dysfunction and renal injury
por: Niknahad, Hossein, et al.
Publicado: (2017)

The effect of sulfasalazine in pentylenetetrazole-induced seizures in rats
por: Bora, E.S., et al.
Publicado: (2021)

Sulfasalazine decreases astrogliosis‐mediated seizure burden
por: Alcoreza, Oscar, et al.
Publicado: (2022)

Induction of ferroptosis by ATF3 elevation alleviates cisplatin resistance in gastric cancer by restraining Nrf2/Keap1/xCT signaling
por: Fu, Dazhi, et al.
Publicado: (2021)

Erastin/sorafenib induces cisplatin-resistant non-small cell lung cancer cell ferroptosis through inhibition of the Nrf2/xCT pathway
por: Li, Yu, et al.
Publicado: (2020)

Silencing of PTPN18 Induced Ferroptosis in Endometrial Cancer Cells Through p-P38-Mediated GPX4/xCT Down-Regulation
por: Wang, Haibo, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9u0gvtkb9obcvce7hl24fkbt1h