Squalamine and Aminosterol Mimics Inhibit the Peptidoglycan Glycosyltransferase Activity of PBP1b

Peptidoglycan (PG) is an essential polymer of the bacterial cell wall and a major antibacterial target. Its synthesis requires glycosyltransferase (GTase) and transpeptidase enzymes that, respectively, catalyze glycan chain elongation and their cross-linking to form the protective sacculus of the ba...

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Detalles Bibliográficos
Autores principales: Boes, Adrien, Brunel, Jean Michel, Derouaux, Adeline, Kerff, Frédéric, Bouhss, Ahmed, Touze, Thierry, Breukink, Eefjan, Terrak, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400108/
https://www.ncbi.nlm.nih.gov/pubmed/32630634
http://dx.doi.org/10.3390/antibiotics9070373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400108/
https://www.ncbi.nlm.nih.gov/pubmed/32630634
http://dx.doi.org/10.3390/antibiotics9070373

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