3-(5-Nitrofuran-2-yl)prop-2-en-1-one Derivatives, with Potent Antituberculosis Activity, Inhibit A Novel Therapeutic Target, Arylamine N-acetyltransferase, in Mycobacteria

In this study, the inhibitory potential of 3-(5-nitrofuran-2-yl)prop-2-en-1-one derivatives was evaluated against a panel of bacteria, as well as mammalian cell lines to determine their therapeutic index. In addition, we investigated the mechanism of antibiotic action of the derivatives to identify...

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Detalles Bibliográficos
Autores principales: Agre, Neha, Tawari, Nilesh, Maitra, Arundhati, Gupta, Antima, Munshi, Tulika, Degani, Mariam, Bhakta, Sanjib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400135/
https://www.ncbi.nlm.nih.gov/pubmed/32630175
http://dx.doi.org/10.3390/antibiotics9070368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400135/
https://www.ncbi.nlm.nih.gov/pubmed/32630175
http://dx.doi.org/10.3390/antibiotics9070368

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