Embelin as Lead Compound for New Neuroserpin Polymerization Inhibitors

Familial encephalopathy with neuroserpin inclusion bodies (FENIB) is a severe and lethal neurodegenerative disease. Upon specific point mutations in the SERPINI1gene-coding for the human protein neuroserpin (NS) the resulting pathologic NS variants polymerize and accumulate within the endoplasmic re...

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Detalles Bibliográficos
Autores principales: Visentin, Cristina, Musso, Loana, Broggini, Luca, Bonato, Francesca, Russo, Rosaria, Moriconi, Claudia, Bolognesi, Martino, Miranda, Elena, Dallavalle, Sabrina, Passarella, Daniele, Ricagno, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400170/
https://www.ncbi.nlm.nih.gov/pubmed/32664592
http://dx.doi.org/10.3390/life10070111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400170/
https://www.ncbi.nlm.nih.gov/pubmed/32664592
http://dx.doi.org/10.3390/life10070111

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