Reactive Metamizole Metabolites Enhance the Toxicity of Hemin on the ATP Pool in HL60 Cells by Inhibition of Glycolysis

Metamizole is an analgesic, whose pharmacological and toxicological properties are attributed to N-methyl-aminoantipyrine (MAA), its major metabolite. In the presence of heme iron, MAA forms reactive metabolites, which are toxic for granulocyte precursors. Since decreased cellular ATP is characteris...

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Detalles Bibliográficos
Autores principales: Rudin, Deborah, Schmutz, Maurice, Roos, Noëmi Johanna, Bouitbir, Jamal, Krähenbühl, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400389/
https://www.ncbi.nlm.nih.gov/pubmed/32674331
http://dx.doi.org/10.3390/biomedicines8070212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400389/
https://www.ncbi.nlm.nih.gov/pubmed/32674331
http://dx.doi.org/10.3390/biomedicines8070212

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